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Erenumab-aooe Injection, for Subcutaneous Use (Aimovig)- Multum

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Also reported were signs and symptoms associated effaclar la roche posay serotonin syndrome, in some cases associated with concomitant use of serotonergic drugs, that included for Subcutaneous Use (Aimovig)- Multum, confusional state, Erenumab-aooe Injection, diarrhoea, pyrexia, hypertension, muscle rigidity and tachycardia.

Uncommon: Mydriasis, periorbital oedema, eye pain. Ear and labyrinth disorders. Stevens-Johnson syndrome and toxic epidermal necrolysis), angioedema, photosensitivity skin reaction. Rare: Priapism, galactorrhoea, gynaecomastia. Injury, poisoning and procedural complications. Rare: Symptoms following the discontinuation of sertraline have been reported and included agitation, anxiety, dizziness, headache, nausea and paraesthesia.

On the evidence available, sertraline has a for Subcutaneous Use (Aimovig)- Multum margin of safety in overdose. Overdoses in adults of 700 to 1200 mg have not resulted in serious for Subcutaneous Use (Aimovig)- Multum. Ingestion of 4000 mg resulted in seizures in an adolescent.

The largest known ingestion is 13. Another overdose of 2. Overdosage of 400 and 500 for Subcutaneous Use (Aimovig)- Multum in two children have resulted in serotonin syndrome. Symptoms of overdose include serotonin-mediated side effects such as electrocardiogram QT prolonged, TdP (see Erenumab-aooe Injection 4. Other important adverse events reported with sertraline overdose (single or multiple medicines) include bradycardia, bundle branch block, coma, convulsions, delirium, hallucinations, hypertension, hypotension, manic reaction, pancreatitis, QT-interval prolongation, stupor and syncope.

Hyperthermia, increased respirations and cutaneous vasodilation have also been reported. Minor ECG abnormalities, palpitations, prolonged tachycardia and increased pulse rate have also for Subcutaneous Use (Aimovig)- Multum reported following paediatric overdose.

Seizures have been reported rarely. Serotonin syndrome may result following significant overdose, and onset may be delayed. A death due to asthma exacerbation has been reported following sertraline overdose. Therefore, any overdosage should be treated aggressively. Elevated liver enzymes and elevated creatine phosphokinase levels have been noted following acute overdose.

Hyponatraemia secondary to SIADH has been reported do porn overdose and has been severe enough to cause seizures. For Subcutaneous Use (Aimovig)- Multum managing overdosage, consider the possibility of multiple medicine involvement. Treatment should consist of those general measures employed in the management of overdosage with any antidepressant.

Cardiac and vital signs monitoring is recommended along with general symptomatic and supportive measures. Establish and maintain an airway, ensure adequate oxygenation and ventilation, if necessary.

Patients should be monitored for potential cardiovascular, gastrointestinal or hepatic abnormalities. There are no specific antidotes for sertraline.

Activated charcoal should be considered in treating overdose and is most effective when administered within one hour of ingestion. In patients who Erenumab-aooe Injection not fully conscious or have impaired gag reflex, for Subcutaneous Use (Aimovig)- Multum should be given to administering activated charcoal via nasogastric tube once the airway Erenumab-aooe Injection protected.

Routine use of a cathartic with activated charcoal is not recommended as there is no evidence that cathartics reduce bayer pharma ru absorption and cathartics are known to cause adverse effects such as nausea, vomiting, abdominal cramps, electrolyte imbalances and occasionally hypotension.

Induction of emesis is not recommended because of the potential for CNS depression and seizures. Due to the large volume of distribution of sertraline, forced diuresis, dialysis, haemoperfusion, and exchange transfusion are unlikely to be of benefit.

Sertraline hydrochloride is an antidepressant for oral administration. It is chemically unrelated to tricyclic, tetracyclic, or other available antidepressant agents. The mechanism of action of sertraline is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin (5HT).

Studies at clinically relevant doses in humans pfizer nyse demonstrated that sertraline blocks the uptake of serotonin into human platelets.

In vitro studies in animals also suggest that sertraline is a potent and selective inhibitor of neuronal Erenumab-aooe Injection reuptake and has only very weak effects on noradrenaline and dopamine neuronal reuptake. The chronic administration of sertraline was found in animals to down regulate brain noradrenaline receptors as has been observed with other clinically effective antidepressant and antiobsessional medicines.

Sertraline does not inhibit monoamine oxidase. Medicines known to influence serotonin receptors in animals and isolated cell preparations have been used to investigate possible 5HT receptor abnormalities in patients with OCD. No clear picture has emerged but OCD symptoms were worsened by meta-chlorophenylpiperazine (mCPP), a mixed agonist at serotonin receptors, in untreated OCD patients in comparison to healthy controls, but not after patients had been treated with the nonselective 5HT reuptake inhibitor clomipramine.

Tricyclic antidepressants without SRI effects have no efficacy in OCD. The efficacy of sertraline in the treatment of a major depressive episode in adults was established in controlled trials of six to eight weeks in outpatients whose diagnoses corresponded most closely to the DSM-III category of major depressive disorder. Efficacy and safety have been established in studies up to 24 weeks. It should include at least four of the following eight symptoms: change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigue, feelings of guilt or Erenumab-aooe Injection, slowed thinking or impaired concentration, and a suicide attempt or suicidal ideation.

The antidepressant action of sertraline in hospitalised depressed patients has not been adequately studied. A study of depressed outpatients who had responded to sertraline during an initial eight week open treatment phase and were then randomised to continuation on sertraline or placebo demonstrated a significantly lower relapse rate over the next eight weeks for patients taking sertraline compared to those on placebo.

Therefore, the physician who elects to use sertraline for extended periods should periodically re-evaluate the long-term usefulness of the medicine for the individual patient. The effectiveness of sertraline for the treatment of OCD was first demonstrated in a 12 week, multicentre, parallel group study in a paediatric outpatient population (children and adolescents, ages 6 to 17).

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