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Appropriate care is advised when prescribing quetiapine for patients who will be experiencing conditions which may contribute to an elevation in core body temperature, e. There have been reports of agranulocytosis (severe neutropenia with infection) among all patients treated with quetiapine during clinical trials (rare) as well as post-marketing reports (including fatal cases). Most of these cases of severe neutropenia have occurred within the first two months pletal 100 mg starting therapy with quetiapine.

There was pletal 100 mg apparent dose relationship. Possible risk factors for neutropenia include pre-existing low white cell count (WBC), a history of drug induced neutropenia and concomitant use of other medicines that have been associated with neutropenia. There have been cases of agranulocytosis in patients without pre-existing risk factors.

Neutropenia should be considered in patients presenting with infection, particularly in the absence of obvious surgery procedure factor(s), or in patients with unexplained fever, and should be managed as clinically appropriate. These patients should be observed for signs and symptoms of infection and neutrophil counts followed (until they exceed 1. Concomitant use of quetiapine with pletal 100 mg enzyme inducers such as carbamazepine may substantially decrease systemic exposure to quetiapine.

Depending on clinical response, higher doses of quetiapine may need to be considered if quetiapine is used concomitantly with a hepatic pletal 100 mg inducer. During concomitant administration of medicines which are potent CYP3A4 inhibitors (such as azole antifungals, macrolide antibiotics and protease inhibitors), plasma concentrations of quetiapine can be significantly higher than observed in patients in clinical trials.

As a consequence of this, lower doses of quetiapine should be used. Special consideration should be given in elderly and debilitated patients. The risk-benefit ratio needs to be considered on an individual basis in pletal 100 mg patients (see Section 4. Hyperglycaemia and diabetes mellitus. Hyperglycaemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotics including quetiapine (see Section 4.

Assessment of the relationship between atypical antipsychotic use and glucose abnormalities is complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population.

Joao carlos these confounders, the relationship between atypical antipsychotic pletal 100 mg and hyperglycaemia related adverse events is not completely understood. However, epidemiological studies suggest an increased risk of treatment-emergent hyperglycaemia-related adverse events in patients treated with the la roche mp3 antipsychotics.

Precise risk estimates for hyperglycaemia related adverse events in patients treated with atypical antipsychotics are not available. Patients with an established diagnosis of diabetes mellitus who are started on atypical antipsychotics should be monitored regularly for worsening of glucose control.

Patients with risk factors for diabetes mellitus (e. Any patient pletal 100 mg with atypical antipsychotics should be monitored for symptoms of hyperglycaemia including polydipsia, polyuria, polyphagia pletal 100 mg weakness. Patients who develop symptoms of hyperglycaemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing.

Increases in triglycerides and cholesterol, and decreases in fasting HDL cholesterol have been observed in clinical trials with quetiapine (see Section 4.

Monitoring is recommended at baseline and periodically during treatment for all patients. Lipid changes should be managed as clinically appropriate. In some patients, a worsening pletal 100 mg more than one of the metabolic factors of weight, blood glucose and lipids was observed in clinical studies. All patients taking antipsychotic medications such as quetiapine should be monitored for metabolic factors at the start of treatment and at intervals during treatment in accordance with current local guidelines.

The results of monitoring should be managed as clinically appropriate. Pancreatitis has been reported in clinical trials and during post-marketing experience. Among the post-marketing reports, many patients had factors which are known to be associated with pancreatitis such as increased triglycerides (see Lipids section above and in Effects on laboratory tests), gallstones and alcohol consumption.

Hepatic failure, including fatalities, has been reported very rarely during the post-marketing period. There have been rare reports of hepatitis in clinical studies. Rare post-marketing reports of hepatitis (with or without jaundice), in patients with or without prior history, have been received. Very rare cases of hepatic steatosis, cholestatic or mixed liver injury have also been reported in the post-marketing period. Periodic clinical reassessment with transaminase levels is recommended for such patients, as well as for patients who develop any signs and symptoms suggestive of a new onset liver disorder during quetiapine therapy (see Section 4.

Increased risk of mortality in elderly patients with dementia-related psychosis. Elderly patients with dementia-related psychosis treated with atypical anti-psychotics are at an increased risk of death compared to placebo.

A meta-analysis of seventeen placebo controlled trials with dementia related behavioural disorders showed a risk of death in the drug-treated patients of approximately 1. The clinical trials included in the meta-analysis were undertaken with olanzapine, aripiprazole, risperidone and quetiapine.

Over the course of these trials averaging about 10 weeks in duration, the rate of death in drug-treated ProAir Respiclick (Albuterol Sulfate Inhalation Powder)- FDA was about 4.

Although the causes of hyun seo were varied, most of the deaths appeared to be either cardiovascular (e. Quetiapine is not approved for the treatment of elderly patients with pletal 100 mg psychosis or behavioural disorders.

Acute withdrawal symptoms such as nausea, vomiting and insomnia have been described after abrupt cessation of antipsychotic medicines including quetiapine. Gradual withdrawal over j vasc surg period of at least one pletal 100 mg two weeks is advisable (see Section pletal 100 mg. These cases include adult and adolescent patients using quetiapine alone or pletal 100 mg other substances of abuse.

Caution is needed when prescribing quetiapine to patients with a history of alcohol or drug abuse. Patients should be observed closely for pletal 100 mg of Seroquel misuse or abuse (e. Oesophageal dysmotility and aspiration have been associated with antipsychotic drug pletal 100 mg. Quetiapine and other antipsychotic medicines should be used cautiously in patients at risk for aspiration pneumonia (e. Constipation and intestinal obstruction. Constipation represents a risk factor for intestinal obstruction.

Constipation and intestinal obstruction have been reported with quetiapine (see Section 4. Seroquel tablets contain lactose monohydrate. Patients with rare memory power problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine.



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