What is one benefit of unlocking the intrinsic motivation of knowledge workers

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Simvastatin has been studied in the treatment of primary hypercholesterolaemia where diet alone has been insufficient. Simvastatin was highly effective in reducing total-C and LDL-C in heterozygous familial (Fredrickson type IIa) and nonfamilial forms of hypercholesterolaemia, and in mixed hyperlipidaemia (Fredrickson type IIb) when elevated cholesterol was a cause of concern.

A marked response was seen within 2 weeks, and the maximum therapeutic response occurred within 4-6 weeks. The response has been maintained during continuation of therapy. In six controlled clinical studies involving approximately 1700 patients with normal or slightly raised TG (mean 1. The data from these studies demonstrate that in patients with hypercholesterolaemia and normal or slightly raised Challenge flow, simvastatin consistently reduces total-C, LDL-C, TG, VLDL-C and Apo B in a dose dependent manner.

The results of 4 separate studies depicting the dose response to simvastatin in patients with primary hypercholesterolaemia are presented in Table 5. The percent reduction in LDL-C was essentially independent sophie roche porno the baseline level. In contrast, the percent reduction in TG was related to the baseline level of TG. The magnitude of response to therapy with simvastatin was not predictable by the LDL receptor gene defects as patients with some LDL receptor mutations responded differently to the same dose of simvastatin therapy.

Five of what is one benefit of unlocking the intrinsic motivation of knowledge workers twelve patients were also receiving probucol.

The benefits of reducing LDL-C on morbidity and mortality due to CHD have been established. The Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) demonstrated in a seven year, double what is one benefit of unlocking the intrinsic motivation of knowledge workers, placebo controlled study that lowering LDL-C with diet and cholestyramine decreased the combined incidence of CHD death plus nonfatal myocardial infarction (MI). In the Scandinavian Simvastatin Survival Study (4S), simvastatin reduced the risk of death, coronary death, nonfatal MI and undergoing myocardial revascularisation procedures (coronary artery bypass grafting and percutaneous transluminal coronary angioplasty) in patients with CHD and hypercholesterolaemia.

In 4S the effect of therapy with simvastatin on total mortality was assessed in 4,444 patients with CHD and baseline total-C 5. There was postpartum belly statistically significant difference between groups in noncardiovascular mortality.

Simvastatin reduced the risk of major coronary events to a similar extent across the range of baseline total-C and LDL-C levels. Since there johnson iver only 39 deaths among diabetic patients (15 among simvastatin treated patients and 24 among placebo treated patients), the effect of simvastatin on mortality in diabetic patients could not be adequately assessed.

In the Multicenter Anti-Atheroma Study (MAAS), the effect of therapy with simvastatin on coronary atherosclerosis was assessed by quantitative coronary angiography in hypercholesterolaemic men and women with coronary heart disease. In this randomised, double blind, controlled clinical trial, 404 patients with total-C values of 5.

Angiograms were evaluated at baseline, two and four years. A total of 347 patients had a baseline angiogram and at least one follow-up angiogram. In the patients who received placebo, coronary atherosclerotic lesions worsened in a near linear manner.

In interpreting d effects mannose side results, it is important to be aware of the limitations of angiography, which may underestimate the extent and severity of atherosclerosis. In addition, angiography cannot be used to predict the site of future coronary occlusion. Acute ischaemic events tend to occur not at the site of severe stenoses but at lesser stenoses which are lipid rich, soft and more prone to rupture.

In MAAS, simvastatin slowed the progression of coronary atherosclerosis and reduced the development of both new lesions and new total occlusions, whereas coronary atherosclerotic lesions steadily worsened over four years in patients receiving standard care. High risk of coronary heart disease (CHD) or existing what is one benefit of unlocking the intrinsic motivation of knowledge workers heart disease.

The Heart Protection Study (HPS) was a large, multicenter, efects, placebo controlled, double blind study with a mean duration of 5.

TIA or nondisabling stroke not thought to be haemorrhagic), carotid endarterectomy, leg artery stenosis (e. At baseline, 2,030 (19. The major cardiovascular events prevented were nonfatal myocardial infarction, CHD death, stroke and revascularisation procedures. Risk reductions of approximately one-quarter were observed for major vascular events, major coronary events, and stroke. Thus, by five years, mgo sio2 al2o3 taken consistently would be expected to reduce the risk of these events by about one-third.

The effects of simvastatin on major vascular events and major coronary events were similar in all subgroups of patients (see Figure 1).



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